NIR has a great potential for in-line and at-line monitoring of bioprocess media and has been used for such applications since the early 1990s. Product titer yield can be enhanced by predicting key analytes in a bioreactor in real-time, allowing for timely control and optimization of nutrient levels as well as checking ammonia and lactate concentration. Both mammalian and microbial cell cultures have been monitored with our laboratory and process instruments with the accuracy and reliability of off-line chemistry methods.
Common biotechnology analytes include: glucose, lactate, ammonia, glutamine, glutamate, product titer, acetate and biomass.
Downloads:
- Monitoring Viable Cell Density in Bioreactors Using Near-Infrared Spectroscopy
- In Situ Monitoring of Osmolality and pH in Bioreactors Using Near-Infrared Spectroscopy
- In Situ Monitoring of CHO Cell Culture Medium Using Near-Infrared Spectroscopy
- Implementation Strategies for Improved Bioprocess Monitoring and Control with Near-Infrared Spectroscopy
- A Guide to Near-Infrared Spectroscopic Analysis of Industrial Manufacturing Processes
- Near-Infrared Absorptions
Links to Analyzers:
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XDS Rapid Liquid Analyzer (RLA) The FOSS Rapid Liquid™ Analyzer provides rapid non-destructive NIR analysis of liquid chemical and pharmaceutical formulations. Read more... |
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XDS Process Analytics MicroBundle Analyzers FOSS' Process analyzers are used throughout the process stream to ensure optimum performance for widely varying samples. The 80-fiber count (40 illumination / 40 collection fibers) allows for cost-effective analysis of sample types ranging from clear liquids to suspensions and solids. Read more... |
