The manufacture of pharmaceutical products from raw material identification to the measurement of content uniformity of dosage forms can be assisted by the implementation of NIR methods. The FDA and European Union health guidelines have increased the workload and rigor associated with receiving inspection, blending and content assay. With the advent of 100% container testing for receiving inspection of raw materials in Europe and Canada, NIR technology can reduce the time and skill level required to meet the increased challenge of compliance.

Common pharmaceutical applications using NIR include: receiving inspection of excipients and API, blend uniformity, granulation, drying and coating and particle size analysis.

Downloads:

• Predicting dissolution profiles using NIR spectroscopy techniques on prolonged release tablets
• NIR Prediction of Solid Dosage Form Dissolution Profiles
• Extending Calibrations for Near-Infrared Assay of Tablets Using Synthetic Modeling and Variance from Placebos
• Near-Infrared Assay and Content Uniformity of Tablets
• Monitoring Granulation Drying Using Near-Infrared Spectroscopy
• In-line Process Analysis of Residual Moisture in a Fluid Bed Granulator-Dryer Using NIR Spectroscopy
• Screening for Counterfeit Drugs Using Near-Infrared Spectroscopy
• Identification of Tablet Formulations inside Blister Packages by NIR Spectroscopy
• Non-Destructive Single Tablet Analysis Using the Rapid Content Analyzer
• Determination of Active Ingredients in Solid (Pharmacuitical) Dosage Forms utilizing solid state standard additions
• A Guide to Near-Infrared Spectroscopic Analysis of Industrial Manufacturing Processes
• Near-Infrared Absorptions

Links to Analyzers:

	XDS Rapid Content Analyzer (RCA) The FOSS Rapid Content™ Analyzer, based on XDS near-infrared technology, provides the next generation of dedicated NIR analysis for rapid non-destructive measurements of solid and liquid chemical and pharmaceutical formulations. Read more...
	XDS MasterLab The FOSS XDS MasterLab™ offers pharmaceutical manufacturers a rapid, reliable test method covering the full array of solid dosage forms: layered, coated or cored tablets, capsules, caplets, geltabs and gelcaps. Read more...
	XDS SmartProbe Analyzer The XDS SmartProbe™ Analyzer is ruggedly manufactured for either the warehouse or plant environments. Read more...
	XDS Rapid Liquid Analyzer (RLA) The FOSS Rapid Liquid™ Analyzer provides rapid non-destructive NIR analysis of liquid chemical and pharmaceutical formulations. Read more...
	XDS Process Analytics MicroBundle Analyzers FOSS' Process analyzers are used throughout the process stream to ensure optimum performance for widely varying samples. The 80-fiber count (40 illumination / 40 collection fibers) allows for cost-effective analysis of sample types ranging from clear liquids to suspensions and solids. Read more...
	XDS Process Analytics Single Fiber Analyzers Typical measurements include reaction monitoring and end point determination in refinery, petrochemical and polymer processes, solvent recovery in pharmaceutical API plants, and analysis of extruded polymer films and coatings. Read more...